Peroxidase-like activity and antimicrobial properties of curcumin-inorganic hybrid nanostructure

KOCA F. D. , Yilmaz D. D. , Onmaz N. E. , ÖÇSOY İ.

Saudi Journal of Biological Sciences, vol.27, no.10, pp.2574-2579, 2020 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 10
  • Publication Date: 2020
  • Doi Number: 10.1016/j.sjbs.2020.05.025
  • Title of Journal : Saudi Journal of Biological Sciences
  • Page Numbers: pp.2574-2579
  • Keywords: Curcumin-hybrid nanostructure, Catalytic activity, Antimicrobial activity, METALLIC NANOPARTICLES, NANOFLOWERS, NANOBIOCATALYST, PLATFORM, EXTRACT, OXIDE, FOOD


© 2020 The AuthorsFor the first time in this study, curcumin was utilized as an organic component reacting with Cu (II) ion (Cu2+) as an inorganic component for fabrication of curcumin based Cu hybrid nanostructure (Cu-hNs). We also systematically examined the catalytic effect towards guaiacol and antimicrobial activities of Cu-hNs towards fish pathogen bacteria. For the characterization of Cu-hNs, Scanning Electron Microscopy (SEM), Energy Dispersive X-ray spectroscopy (EDX) and Fourier transform infrared spectrometry (FT-IR) analysis were used. We claimed that hydroxyl group might react with Cu2+ in phosphate solution (PO4-3) to form Cu-hNs. However, more uniform and spherical Cu-hNs were not seen owing to absence of more reactive functional groups like amine and carboxyl groups on structure of curcumin. In addition to our findings, synthesis of Cu-hNs were carried out in the various pH values to evaluate the effect of pHs on formation of Cu-hNs. The Cu-hNs exhibited remarkable catalytic activity throught the Fenton reaction in the presence of hydrogen peroxide (H2O2) and effective antimicrobial activities against Gram-positive/negative fish pathogen bacteria. In this study, cheap and efficient synthesis of nanoflowers (NFs) using plant extracts is proposed for biomedical applications rather than expensive molecules such as amino acids and DNA.