The Etiology and Clinical Features of Non-CAH Gonadotropin-Independent Precocious Puberty: A Multicenter Study

Atay, Zeynep; YESILKAYA, Ediz; ERDEVE, Senay; Turan, Serap; AKIN, Leyla; Eren, Erdal; Doger, Esra; AYCAN, Zehra; Abali, Zehra; AKINCI, AYŞEHAN; Şıklar, Zeynep; Özen, Samim; KARA, Cengiz; Tayfun, Meltem; SARI, Erkan; Tütüncüler, Filiz; Karabulut, Gulcan; Karagüzel, Gulay; Çetinkaya, Semra; Sağlam, Halil; Bideci, Aysun; Kurtoglu, Selim; Güran, Tulay; Bereket, Abdullah

doi:10.1210/jc.2015-3500

The Etiology and Clinical Features of Non-CAH Gonadotropin-Independent Precocious Puberty: A Multicenter Study

Atay Z., YESILKAYA E., ERDEVE S. S., Turan S., AKIN L., Eren E., ...More

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol.101, no.5, pp.1980-1988, 2016 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 101 Issue: 5
Publication Date: 2016
Doi Number: 10.1210/jc.2015-3500
Journal Name: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1980-1988
Erciyes University Affiliated: Yes

Abstract

Aim: The causes of gonadotropin-independent precocious puberty are diverse, and often have overlapping clinical and biochemical features. With the exception of congenital adrenal hyperplasia (CAH), disorders that cause gonadotropin-independent precocious puberty (GIPP) are uncommon. The literature is devoid of any large-scale studies on the etiologic distribution of GIPP. The aim of this study was to determine the frequency of each etiology in a cohort of patients with GIPP (excluding those with CAH), and to evaluate the clinical and laboratory features of these patients.