In today's world, logistic centers not only play an important roles in sustaining the nation's economy, they also significantly contribute to the economic and social development of the regions in which they are located. The layout of the center is crucial in ensuring that such important centers are both efficient and productive. To achieve this, this study focuses on the development of a logistic center layout that is integrated with the ant colony optimization algorithm. To this end, the logistic center area layout was developed by applying the developed algorithm to an actual logistic center planned to be constructed. The efficiency of the suggested algorithm was tested in accordance with the benchmark problems in the literature. In addition, a case study was carried out to illustrate the effectiveness of the proposed approach. The obtained results revealed that the suggested algorithm provided more efficiency than other layouts.