Diagnostic value of troponin T in neonates of mild pre-eclamptic mothers


Narin N. , Çetin N. , Kilic H. , Basbug M. , Narin F. , Kafalı M. E. , ...Daha Fazla

BIOLOGY OF THE NEONATE, cilt.75, ss.137-142, 1999 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 75 Konu: 2
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1159/000014089
  • Dergi Adı: BIOLOGY OF THE NEONATE
  • Sayfa Sayıları: ss.137-142

Özet

The measurement of myocardial damage by newer, highly specific markers of myocardial damage is now possible, including cardiac structural proteins such as troponin T (TnT). in neonates of pre-eclamptic mothers, it identifies minor myocardial damage missed by other biochemical markers. The present study was designed to determine the diagnostic value of TnT concentrations in neonates of pre-eclamptic mothers. Fifteen neonates of pre-eclamptic mothers were studied (9 boys and 6 girls), and 17 healthy full-term neonates (9 boys and 8 girls) were selected as a control group. The serum TnT concentration in neonates of pre-eclamptic mothers (0.70 ng/ml) was significantly higher than that in the control group (0.10 ng/ml). in an echocardiographic study, the mean mitral peak velocity at an atrial contraction (A) value of 39 cm/s in neonates of pre-eclamptic mothers was significantly lower than that in the control group (53 cm/s), and the mean mitral peak velocity of early diastole to peak velocity of the atrial contraction (E/A) value (1.75) in neonates of pre-eclamptic mothers was significantly higher than that in the control subjects (1.23). In conclusion, our study demonstrated high levels of cardiac TnT, lower mitral A values and high mitral E/A values in neonates of pre-eclamptic mothers, presumably associated with mild myocardial damage in the neonates of pre-eclamptic mothers.