Hematologic Parameters and Angiographic Progression of Coronary Atherosclerosis

Kalay N., Dogdu O., Koc F., Yarlioglues M., Ardic I., Akpek M., ...More

ANGIOLOGY, vol.63, no.3, pp.213-217, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1177/0003319711412763
  • Journal Name: ANGIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.213-217
  • Keywords: hematologic parameters, neutrophil/lymphocyte ratio, progression, atherosclerosis, DENSITY-LIPOPROTEIN CHOLESTEROL, LIFE-STYLE MODIFICATION, PLAQUE PROGRESSION, ARTERY-DISEASE, MORTALITY, RISK
  • Erciyes University Affiliated: Yes


Hematologic parameters have prognostic importance in cardiovascular disease. However, the relation between atherosclerosis progression and hematologic parameters is not well defined. A total of 394 patients requiring repeat coronary angiography were included in the study. According to angiography, patients were divided into 2 groups, progressive (n = 196) and nonprogressive (n = 198) diseases. Hematologic parameters including mean platelet volume (MPV) and neutrophil/lymphocyte (N/L) ratio were measured. Glucose, creatinine, and cholesterol were significantly higher in the progressive group. Mean platelet volume count was similar in both groups. The N/L ratio was significantly higher in the progressive group (5.0 +/- 5.1 vs 3.2 +/- 3; P = .001). In multivariate analysis, the N/L ratio was significantly related with progression (relative risk [RR]: 2.267, 95% CI: 1.068-4.815, P = .03). Progression rate was significantly high in patients with high N/L ratio (39% vs 56%). Our results suggest that the N/L ratio is a predictor of progression of atherosclerosis.