Clinical Trials Based on Mesenchymal Stromal Cells are Exponentially Increasing: Where are We in Recent Years?


Galderisi U., Peluso G., Di Bernardo G.

STEM CELL REVIEWS AND REPORTS, cilt.18, sa.1, ss.23-36, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s12015-021-10231-w
  • Dergi Adı: STEM CELL REVIEWS AND REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.23-36
  • Anahtar Kelimeler: Mesenchymal stem cells, Stem cells, Clinical trials, Stromal cells, VERSUS-HOST-DISEASE, STEM-CELLS, BONE-MARROW, STEROID-RESISTANT, MYOCARDIAL-INFARCTION, INTERNATIONAL-SOCIETY, MULTIPLE-SCLEROSIS, ISCHEMIC-HEART, THERAPY, TRANSPLANTATION
  • Erciyes Üniversitesi Adresli: Hayır

Özet

Mesenchymal stromal cells (MSCs), present in the stromal component of several tissues, include multipotent stem cells, progenitors, and differentiated cells. MSCs have quickly attracted considerable attention in the clinical field for their regenerative properties and their ability to promote tissue homeostasis following injury. In recent years, MSCs mainly isolated from bone marrow, adipose tissue, and umbilical cord-have been utilized in hundreds of clinical trials for the treatment of various diseases. However, in addition to some successes, MSC-based therapies have experienced several failures. The number of new trials with MSCs is exponentially growing; still, complete results are only available for a limited number of trials. This dearth does not help prevent potentially inefficacious and unnecessary clinical trials. Results from unsuccessful studies may be useful in planning new therapeutic approaches to improve clinical outcomes. In order to bolster critical analysis of trial results, we reviewed the state of art of MSC clinical trials that have been published in the last six years. Most of the 416 published trials evaluated MSCs' effectiveness in treating cardiovascular diseases, GvHD, and brain and neurological disorders, although some trials sought to treat immune system diseases and wounds and to restore tissue. We also report some unorthodox clinical trials that include unusual studies.