Akademik Veri Yönetim Sistemi
10. Uluslararası Katılımlı Erciyes Tıp Tıbbi Genetik Kongresi, Kayseri, Türkiye, 12 Haziran - 14 Ekim 2025, ss.38, (Özet Bildiri)
Introduction: Dientamoebiasis is an infection caused by Dientamoeba fragilis. Data on the relationship between the molecular types of this parasitosis, which is of increasing importance especially in cancer patients, and cancer diseases are limited. This study aimed to obtain new data on the relationship between its molecular characteristics and the disease. Materials and Methods: The study included stool samples collected from patients and healthy volunteers who would form the control group. In the study, PCR and qPCR tests were performed after total genomic DNA isolation of the collected samples, and phylogenetic characterization was performed by obtaining sequence analysis of the samples found to be positive for Dientamoeba fragilis. Discussion: Accordingly, 6 patient was detected as positive with standard PCR, while 11 patient was detected as positive with qPCR. It was shown that there was no significant difference in the distribution of the parasite between male and female patients diagnosed with cancer. The different genotype was detected in cases infected with D. fragilis. Results: In conclusion, this study has shown that there may be a molecular relationship between patients diagnosed with cancer and the genotypes detected in this parasite, which is thought to affect clinical findings. It is a study that sheds light on the effect of the genotypes of the parasite on clinical symptoms in the cases included in the study. It is thought that this study will contribute to diagnostic studies as well as epidemiological studies.