The role of midtrimester amniotic fluid leptin and endothelin-1 levels in prediction of preeclampsia Midtrimester amniyotik sivi leptin ve endotelin-1 düzeylerinin preeklampsi gelişiminin öngörüsündeki rolü


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TAYYAR A. , Tayyar A. T. , ABDÜLREZZAK Ü. , KULA M. , TAŞ M. , TAYYAR M.

Turk Jinekoloji ve Obstetrik Dernegi Dergisi, vol.9, no.1, pp.37-41, 2012 (Refereed Journals of Other Institutions) identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 1
  • Publication Date: 2012
  • Doi Number: 10.5505/tjod.2012.42204
  • Title of Journal : Turk Jinekoloji ve Obstetrik Dernegi Dergisi
  • Page Numbers: pp.37-41

Abstract

Objective: We investigated leptin and endothelin-1 levels of amniotic fluid (AF) which was collected during genetic
amniocentesis to use these parameters for prediction of preeclampsia.
Meterial and methods: The level of leptin and endothelin-1 were measured in the samples of AF which were obtained
at 16-20 weeks of pregnancy during genetic amniocentesis. We recorded the patients who developed preeclampsia
and who had healthy pregnancy and birth.
Results: AF leptin and endothelin-1 levels were significantly increased in the preeclamptic group compared to control group.
Conclusion: As we detected increased level of AF leptin and endothelin-1 before preeclampsia symptoms develop
we think that these proteins can be used to predict preeclampsia. Thus, early follow up and treatment of preeclampsia
could decrease possible complications and related financial expense.

Amaç: Genetik amniyosentez örneklerinde leptin ve endotelin-1 düzeylerini inceleyerek bunlar›n preeklampsi geliflimini
tahmin etmede kullan›p kullan›lamayaca¤›n› araflt›rmak.
Gereç ve yöntemler: Genetik amniyosentezle 16-20 haftal›k gebelerden al›nan amniyotik s›v› (AS) örneklerinde leptin
ve endotelin-1 düzeylerini araflt›rd›k. Prospektif yap›lan takiplerde preeklampsi geliflen ve sa¤l›kl› do¤um yapan
hastalar› kaydettik.
Bulgular: Preeklampsi geliflen grupta AS leptin ve endotelin-1 düzeyleri kontrol grubundan istatistiksel olarak yüksek
bulunmufltur.
Yorum: AS'de henüz preeklampsi bulgular› ortaya ç›kmadan önce leptin ve endotelin-1'in yüksek düzeyde bulunmas› nedeniyle
bu proteinlerin preeklampsiyi önceden tahmin etmede kullan›labilece¤ini düflünmekteyiz. Böylece preeklampsi takip ve tedavisinin
erken bafllat›lmas› ile olas› komplikasyonlar›n ve bunlara ba¤l› oluflacak maddi giderlerin azalt›lmas› mümkün olabilecektir.