Sustained release of neuron-specific enolase to serum in amateur boxers

Zetterberg H., TANRIVERDİ F., ÜNLÜHİZARCI K., SELÇUKLU A., Kelestimur F., Blennow K.

BRAIN INJURY, vol.23, no.9, pp.723-726, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 9
  • Publication Date: 2009
  • Doi Number: 10.1080/02699050903120399
  • Journal Name: BRAIN INJURY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.723-726
  • Keywords: Boxing, biomarkers, neuron-specific enolase, brain injury, TRAUMATIC BRAIN-INJURY, ACUTE ISCHEMIC-STROKE, ACID-BINDING PROTEINS, NEUROBIOCHEMICAL MARKERS, BIOCHEMICAL MARKERS, CEREBROSPINAL-FLUID, DAMAGE, CHILDREN, BIOMARKERS, MANAGEMENT
  • Erciyes University Affiliated: Yes

Abstract

Primary objective: We assess the potential of a panel of serum biomarkers to identify chronic neuronal injury in amateur boxers as compared to healthy controls without any history of head trauma. Research design: Observational case-control study. Methods and procedures: A panel of serum biomarkers was measured by a novel biochip array technique on the Evidence Investigator. Serum samples were taken after a 2-month period of nonparticipation in boxing. Main outcomes and results: Boxers had higher serum levels of neuron-specific enolase (NSE, median [range] 11 [2.3-41] ng/mL) than controls (4.8 [0.78-27] ng/mL, p = 0.014) but unchanged levels of the other brain damage biomarker candidates, S-100B, brain-derived neurotrophic factor and heart-type fatty acid binding protein. Conclusions: The more than doubled median serum level of NSE in boxers after an extended resting period suggests that repetitive head trauma results in sustained release of this brain-specific protein to the peripheral circulation.