Toxicokinetic of phenothrin in rabbits

Kaya T., ERASLAN G.

VETERINARSKI ARHIV, cilt.91, sa.5, ss.547-558, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 91 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.24099/vet.arhiv.1064
  • Dergi Adı: VETERINARSKI ARHIV
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Veterinary Science Database
  • Sayfa Sayıları: ss.547-558
  • Anahtar Kelimeler: phenothrin, toxicokinetic, oral, intravenous, rabbit, PYRETHROID INSECTICIDES, GAS-CHROMATOGRAPHY, TETRAMETHRIN ISOMERS, TISSUE DISTRIBUTION, TRANS-PERMETHRIN, METABOLISM, RAT, DELTAMETHRIN, BIFENTHRIN, PLASMA
  • Erciyes Üniversitesi Adresli: Evet

Özet

The toxicokinetics of single dose phenothrin were examined in rabbits. For this aim, a total of 14 New Zealand breed, 2 to 2.5 kg body weight, 6 month-old female rabbits were used. The animals were divided into two groups and each group had 7 animals. Phenothrin was administered intravenously to each animal in group 1, at a dose of 10 mg/kg b.w. and orally to each of the animals in group 2 at the same dose. Dimethyl sulfoxide was used as a solvent in application of phenothrin. Plasma phenothrin levels were measured by gas chromatography equipped with an ECD detector. Toxicokinetic evaluations were made according to the plasma phenothrin level-time curve. Phenothrin was found to be distributed according to the two-compartment open model. The values of elimination half-life (t(1/2 beta)), mean residence time (MRT) and area under the curve (AUC(0 ->infinity)) after intravenous phenothrin administration were 2.57 +/- 0.10 h, 2.79 +/- 0.09 h and 6893.05 +/- 261.26 ng/h/mL, respectively. On the other hand, the maximum plasma concentration (C-max), time to reach C-max (t(max)), t(1/2 beta), MRT and AUC(0 ->infinity) after oral administration were 185.71 +/- 8.21 ng/mL, 1.21 +/- 0.20 h, 4.24 +/- 0.39 h, 6.65 +/- 0.54 h and 1054.04 +/- 65.90 ng/h/mL, respectively. The oral bioavailability of phenothrin was calculated as 15.29%. Mean residence time was short and oral bioavailability was low. This may be one of the reasons why phenothrin is included in safe pesticides.