Preparation of novel pyrrol-2-one derivatives via an effective synthesis of new oxazole scaffold


Kibriz I. E. , SAÇMACI M., ŞAHİN E., YILDIRIM I.

TETRAHEDRON, cilt.73, ss.1795-1802, 2017 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 73 Konu: 14
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.tet.2017.01.046
  • Dergi Adı: TETRAHEDRON
  • Sayfa Sayıları: ss.1795-1802

Özet

A convenient procedure for the preparation of oxazole and pyrrole derivatives is described. 2-Amino-1,3-oxazol-2-ones 3a,b were first synthesized from the cyclocondensation reactions of cyanamide (2) with 4-ethoxycarbonyl-5-aryl-2,3-furandione 1a,b, and then new pyrrol-2-ones 5 were synthesized from the reaction of the compounds 3 with various aromatic amines 4. (C) 2017 Published by Elsevier Ltd.