Nuclear protein contents in peripheral blood mononuclear cells of trisomy 21 infants


HAMURCU Z. , DEMIRTAS H., Patiroglu T., KUMANDAŞ S.

CYTOMETRY PART B-CLINICAL CYTOMETRY, no.2, pp.128-132, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2008
  • Doi Number: 10.1002/cyto.b.20387
  • Title of Journal : CYTOMETRY PART B-CLINICAL CYTOMETRY
  • Page Numbers: pp.128-132

Abstract

Objective: The trisomy 21 (Ts21) or Down's syndrome (DS) phenotype is assumed to occur primarily by the expression/overexpression of some genes encoded by the extra chromosome 21. It has recently been shown by AgNOR staining that babies with Ts21 have more AgNOR area (more NOR proteins) and more RNA content in their peripheral blood mononuclear cells (PBMCs) than those of controls. The aim of this study was to test whether or not the nuclear proteins content of PBMCs from trisomy 21 babies/infants is higher than that of the controls.