Effect of Mg2SO4 usage on spinal cord ischemia-reperfusion injury: Electron microscopic and functional evaluation

Kaplan S., Ulus A., Tutun U., Aksoyek A., Ozgencil E., Saritas Z., ...More

EUROPEAN SURGICAL RESEARCH, vol.36, no.1, pp.20-25, 2004 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 1
  • Publication Date: 2004
  • Doi Number: 10.1159/000075070
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.20-25
  • Erciyes University Affiliated: Yes


Objectives: To evaluate the effects of intravenous magnesium sulfate (Mg2SO4) administration on ischemia-reperfusion injury of the spinal cord. Material and Methods: Sixteen rabbits were randomly assigned to the control ( group I, 8 rabbits) and the study group ( group II, 8 rabbits). The abdominal aorta was clamped for a period of 30 min followed by a reperfusion period of 60 min. The animals in group II received 0.25 ml/kg/h Mg2SO4 intravenous infusion (15% Mg2SO4) throughout this procedure. The animals were then observed for 24 h after which their neurological states were evaluated and tissue samples obtained from the spinal cord were examined with electron microscopy. Results: Aortic pressure distal to the cross-clamp during the occlusion period was 9 +/- 3 mm Hg in group I and 19 +/- 6 mm Hg in group II. All animals in group I were paraplegic at the end of the study. In group II the neurological outcome of 1 animal was poor while the other 7 animals were neurologically in a good condition. Electron microscopic examinations of the spinal cord tissues of group I revealed severe injury but the ultrastructure was well preserved in group II. Conclusions: Intravenous Mg2SO4 administration may have protective effects on the ischemia-reperfusion injury of the spinal cord. We propose that Mg2SO4 may be an additional protective pharmacological agent in thoracal and thoracoabdominal aortic surgery. Copyright (C) 2004 S. Karger AG, Basel.