Elevated Hyaluronan Levels in Patients with Rheumatic Mitral Stenosis and Pulmonary Arterial Thromboembolism

KALAY N., ELÇİK D., Savas G., Altın P., Sakalar C., Kaya O., ...More

HEART LUNG AND CIRCULATION, vol.23, no.7, pp.649-654, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 7
  • Publication Date: 2014
  • Doi Number: 10.1016/j.hlc.2014.01.011
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.649-654
  • Keywords: Hyaluronan, Rheumatic mitral stenosis, Pulmonary arterial thromboembolism, Pulmonary arterial hypertension, Percutaneous mitral balloon valvuloplasty, MATRIX-METALLOPROTEINASE INHIBITION, EXTRACELLULAR-MATRIX, VASCULAR-RESISTANCE, COMMISSUROTOMY, HYPERTENSION, ACTIVATION, ACID
  • Erciyes University Affiliated: Yes


Introduction: The role of hyaluronan (HA) was previously demonstrated in patients with idiopathic pulmonary arterial hypertension (PAH). Mitral stenosis (MS) and pulmonary arterial thromboembolism (PTE) are important health problems that can cause pulmonovascular pathology. Pulmonary arterial hypertension develops especially in untreated patients with severe MS and most of patients with PTE. However, there is no data about HA levels in patients with MS and PTE. In this study, we investigated HA levels in patients with rheumatic MS and PTE.