Increased micronucleus frequency after oral administration of cadmium in dogs

Donmez-Altuntas H., Hamurcu Z., Liman N., Demirtaş H., Imamoglu N. N.

BIOLOGICAL TRACE ELEMENT RESEARCH, vol.112, no.3, pp.241-246, 2006 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 112 Issue: 3
  • Publication Date: 2006
  • Doi Number: 10.1385/bter:112:3:241
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.241-246
  • Erciyes University Affiliated: Yes


Cadmium (Cd) is a toxic heavy metal that has been classified as a human carcinogen by the International Agency for Research on Cancer. The genotoxic effects of cadmium oxide (CdO) were investigated in cultured dog lymphocytes after a short-term oral CdO administration by the micronucleus (MN) test. The dogs were given 10 mg CdO/kg body weight per day for 3 and 28 d, respectively group I (n = 7) and group II (n = 6). Blood samples were collected at the beginning of feeding and at 4 and 29 d after Cd administration and cultured for 72 h. Whereas no significant increase in the MN frequency in group I was observed (p = 0.398), a significant MN induction with CdO was found in group II (p = 0.028) when compared with initial MN frequencies of dogs in both groups. Our results suggest that CdO might be directly and/or indirectly genotoxic after a monthly oral administration of CdO in dogs.