Beneficial effect of pine honey on trichlorfon induced some biochemical alterations in mice

ERASLAN G., KANBUR M., SİLİCİ S., KARABACAK M.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, cilt.73, sa.5, ss.1084-1091, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 73 Sayı: 5
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.ecoenv.2010.02.017
  • Dergi Adı: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1084-1091
  • Anahtar Kelimeler: Beneficial effect, Trichlorfon, Pine honey, Oxidative stress, Biochemical alterations, Mice, ANTIOXIDANT DEFENSE SYSTEMS, OXIDATIVE STRESS, LIPID-PEROXIDATION, IN-VITRO, BIOMARKERS, RATS, ERYTHROCYTE, FLAVONOIDS, PROPOLIS, SAMPLES
  • Erciyes Üniversitesi Adresli: Evet

Özet

Forty-eight male BALB/c mice, weighing 30-35 g, were used in the study, and were divided into groups of 12 each. The four groups established in the study included one control group and three experimental groups. The first group served as the control group, while Groups 2, 3 and 4 were administered 1 g/kg bw/day pine honey, 180 mg/kg bw/day trichlorfon (similar to 1/5LD(50)) and 1 g/kg bw/day pine honey plus 180 mg/kg bw/day trichlorfon, respectively, by the oral route using a catheter for 21 days. At the end of 21 days post-administration, blood and tissue (liver, kidney, brain and heart) samples were collected. Serum levels/activities of total protein, albumin, glucose, cholesterol, triglyceride, BUN, creatine, uric acid, magnesium, sodium, potassium, chloride, total bilirubin, GGT, LDH, AST, ALT and ALP were determined. Furthermore, tissue MDA levels and CAT, SOD and GSH-Px activities were analyzed. According to the data obtained, when administered at the indicated dose and for the indicated time period, trichlorfon was determined to lead to negative alterations in most of the biochemical parameters investigated. The administration of pine honey was determined to alleviate this effect. (C) 2010 Elsevier Inc. All rights reserved.