Synthesis and Crystal Structure of 3-Amino-1-(5-Chloro-2-Hydroxyphenyl)Imidazolidine-2,4-Dione

Aydin A., Onkol T., AKKURT M., Buyukgungor O., Sahin M. F.

MOLECULAR CRYSTALS AND LIQUID CRYSTALS, cilt.570, sa.1, ss.119-127, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 570 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1080/15421406.2012.707593
  • Dergi Adı: MOLECULAR CRYSTALS AND LIQUID CRYSTALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.119-127
  • Erciyes Üniversitesi Adresli: Evet

Özet

The present study describes the synthesis, spectral data, and single crystal X-ray structural analysis of 3-amino-1-(5-chloro-2-hydroxyphenyl)imidazolidine-2,4-dione. X-Ray analysis revealed that the title compound did not have the anticipated structure, but had that of a different substance. This unexpected conformation generated the interest in studying the synthesis of this compound. The inspected compound, 3-amino-1-(5-chloro-2-hydroxyphenyl)imidazolidine-2,4-dione, is a pharmaceutical intermediate and is nonplanar. Its benzene and five-membered rings have a dihedral angle of 53.95(7)degrees. The conformation is stabilized by intermolecular OH ... O, OH ... N, and NH ... O interactions and a weak CH ... interaction.