Neutrophil-Lymphocyte Ratio as a Predictor of Disease Severity in Ulcerative Colitis


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Çelikbilek M. , Dogan S. , ÖZBAKIR Ö. , ZARARSIZ G. , Küçük H. , GÜRSOY Ş. , et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS, cilt.27, ss.72-76, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 27 Konu: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1002/jcla.21564
  • Dergi Adı: JOURNAL OF CLINICAL LABORATORY ANALYSIS
  • Sayfa Sayısı: ss.72-76

Özet

BackgroundBlood neutrophil-to-lymphocyte (N/L) ratio is an indicator of the overall inflammatory status of the body, and an alteration in N/L ratio may be found in ulcerative colitis (UC) patients. The aims of this study were to investigate the utility of N/L ratio as a simple and readily available predictor for clinical disease activity in UC. J. Clin. Lab. Anal. 27:72-76, 2013. (c) 2012 Wiley Periodicals, Inc.
BACKGROUND: Blood neutrophil-to-lymphocyte (N/L) ratio is an indicator of the overall inflammatory status of the body, and an alteration in N/L ratio may be found in ulcerative colitis (UC) patients. The aims of this study were to investigate the utility of N/L ratio as a simple and readily available predictor for clinical disease activity in UC. METHODS: Twenty-six patients and 28 healthy controls were enrolled in the study. The neutrophil and lymphocyte counts were recorded, and the N/L ratio was calculated from these parameters. The extent of disease classified according to the Montreal classification, clinical disease activity was evaluated using a modified Truelove-Witts severity index, and endoscopic disease activities were classified according to Schroder et al. RESULTS: The serum N/L ratios of active patients were significantly higher than those of inactive UC and controls (P < 0.001). The optimum N/L ratio cut-off point for active UC was 2.47. There was no significant difference between inflammation parameters, disease extension, and disease activity. CONCLUSION: Our results demonstrate that N/L ratio is higher in patients with active UC compared with controls and UC patients in remission and a cut-off value of 2.47 can be used to identify patients with active ulcerative colitis.