Adverse fetal outcomes in patients with IUGR are related with fetal diaphragm evaluation parameters


Acmaz G., Ozdemir F., Sahin E., Sahin M. E., Madendag Y., Demir T. B., ...More

PAEDIATRIC RESPIRATORY REVIEWS, vol.37, pp.48-53, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37
  • Publication Date: 2021
  • Doi Number: 10.1016/j.prrv.2020.07.005
  • Journal Name: PAEDIATRIC RESPIRATORY REVIEWS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.48-53
  • Keywords: IUGR, Diaphragmatic thickness, Diaphragmatic excursion, Diaphragm thickening fraction
  • Erciyes University Affiliated: Yes

Abstract

Introduction: The aim of the present study was to evaluate the relationship between diaphragmatic thickness, during both inspiratory (DTI) and expiratory (DTE) stages; diaphragmatic excursion (DE); diaphragm thickening fraction (DTF); and adverse fetal outcomes in pregnant women with intrauterine growth restriction (IUGR). Materials and methods: A total of 77 participants were included in this case-control study. The case group was diagnosed as having both symmetric and asymmetric IUGR (n = 39). The control group included gestational age (GA)-matched healthy pregnant women (n = 38). DTI, DTE, DE (reflecting the capability of diaphragmatic movement during the respiratory cycle), and DTF were analyzed. Results: Maternal demographic characteristics were similar between groups. DTI and DTE were significantly lower in the IUGR group compared to the control group (p < 0.001 and p < 0.001). DE was similar between the groups (p = 0.07). Additionally, in the IUGR group, DTI, DTE, and DE were significantly altered in newborns that required treatment in the neonatal intensive care unit (NICU). ROC curve analysis determined that the DTI cut-off was 1.36 for NICU admission with 78% sensitivity and 100% specificity. DTE cut-off was 1.195 for NICU admission with 78% sensitivity and 96% specificity. DE cut-off was 4.25 for NICU admission with 71% sensitivity and 80% specificity. Conclusion: Measurement of DTI, DTE and DE may help clinicians to predict whether newborns with IUGR would require NICU hospitalization. (c) 2020 Elsevier Ltd. All rights reserved.