Increased genome instability and oxidative DNA damage and their association with IGF-1 levels in patients with active acromegaly


BAYRAM F. , Bitgen N. , Donmez-Altuntas H. , Cakir I. , HAMURCU Z. , Sahin F., ...More

GROWTH HORMONE & IGF RESEARCH, vol.24, no.1, pp.29-34, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.1016/j.ghir.2013.12.002
  • Title of Journal : GROWTH HORMONE & IGF RESEARCH
  • Page Numbers: pp.29-34

Abstract

Objective: The objectives of this study were to assess cytokinesis-block micronucleus cytome (CBMN Cyt) assay parameters and also oxidative DNA damage in patients with active acromegaly and controls and to assess the relationship between age, serum insulin-like growth factor 1 (IGF-1) levels, pituitary adenoma diameters, 8-hydroxy-2 '-deoxyguanosine (8-OHdG) levels and CBMN Cyt assay parameters in patients with active acromegaly.