Increased genome instability and oxidative DNA damage and their association with IGF-1 levels in patients with active acromegaly

BAYRAM, FAHRİ; Bitgen, NAZMİYE; Donmez-Altuntas, HAMİYET; Cakir, Ilkay; HAMURCU, ZÜHAL; Sahin, Fatma; Simsek, Yasin; BAŞKOL, GÜLDEN

doi:10.1016/j.ghir.2013.12.002

Increased genome instability and oxidative DNA damage and their association with IGF-1 levels in patients with active acromegaly

BAYRAM F., Bitgen N., Donmez-Altuntas H., Cakir I., HAMURCU Z., Sahin F., ...Daha Fazla

GROWTH HORMONE & IGF RESEARCH, cilt.24, sa.1, ss.29-34, 2014 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 24 Sayı: 1
Basım Tarihi: 2014
Doi Numarası: 10.1016/j.ghir.2013.12.002
Dergi Adı: GROWTH HORMONE & IGF RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.29-34
Anahtar Kelimeler: Acromegaly, CBMN Cyt assay, IGF-1, 8-OHdG levels, MN frequency
Erciyes Üniversitesi Adresli: Evet

Özet

Objective: The objectives of this study were to assess cytokinesis-block micronucleus cytome (CBMN Cyt) assay parameters and also oxidative DNA damage in patients with active acromegaly and controls and to assess the relationship between age, serum insulin-like growth factor 1 (IGF-1) levels, pituitary adenoma diameters, 8-hydroxy-2 '-deoxyguanosine (8-OHdG) levels and CBMN Cyt assay parameters in patients with active acromegaly.