Increased genome instability and oxidative DNA damage and their association with IGF-1 levels in patients with active acromegaly

BAYRAM, FAHRİ; Bitgen, NAZMİYE; Donmez-Altuntas, HAMİYET; Cakir, Ilkay; HAMURCU, ZÜHAL; Sahin, Fatma; Simsek, Yasin; BAŞKOL, GÜLDEN

doi:10.1016/j.ghir.2013.12.002

Increased genome instability and oxidative DNA damage and their association with IGF-1 levels in patients with active acromegaly

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BAYRAM F., Bitgen N., Donmez-Altuntas H., Cakir I., HAMURCU Z., Sahin F., ...More

GROWTH HORMONE & IGF RESEARCH, vol.24, no.1, pp.29-34, 2014 (SCI-Expanded)

Publication Type: Article / Article
Volume: 24 Issue: 1
Publication Date: 2014
Doi Number: 10.1016/j.ghir.2013.12.002
Journal Name: GROWTH HORMONE & IGF RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.29-34
Keywords: Acromegaly, CBMN Cyt assay, IGF-1, 8-OHdG levels, MN frequency, MICRONUCLEUS CYTOME ASSAY, HUMAN-LYMPHOCYTES, CANCER-RISK, PROSTATE-CANCER, GROWTH, POPULATION, AXIS, GENOTOXICITY, PREVALENCE, FREQUENCY
Erciyes University Affiliated: Yes

Abstract

Objective: The objectives of this study were to assess cytokinesis-block micronucleus cytome (CBMN Cyt) assay parameters and also oxidative DNA damage in patients with active acromegaly and controls and to assess the relationship between age, serum insulin-like growth factor 1 (IGF-1) levels, pituitary adenoma diameters, 8-hydroxy-2 '-deoxyguanosine (8-OHdG) levels and CBMN Cyt assay parameters in patients with active acromegaly.