We identified four patients with multiple gastrointestinal stromal tumors (GIST) in small bowel. Three of the adult patients have neurofibromatosis type 1 (NF1) and one patient have neither NF1 nor any other familial disorder. Immunostains for CD117, CD34, desmin, actins, S-100 protein, and keratins were performed on all of the tumors. Patient's ages/genders were 65/F, 66/M, 36/M and 65/F. All of the patients had multiple GISTs in small bowel; at least three nodules at the size of average 3.0 cm (0.2 mm-12 cm). The first patient had incidental somatostatinoma in ampulla vatery at the same time, and the second one had synchronously adenomyoma in ampulla vatery and gastric adenocarcinoma metachronously, third one was found incidentally during his invagination operation and the fourth one had gastrointestinal stromal tumor metastasis in liver and had thyroid papillary carcinoma (TPC) twenty years before. GISTs may present with other rare tumors.