Ipilimumab-associated cholestatic hepatitis: a case report and literature review

Yildirim S., DENİZ K., Dogan E., BAŞKOL M., GÜRSOY Ş., ÖZKAN M.

MELANOMA RESEARCH, cilt.27, sa.4, ss.380-382, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1097/cmr.0000000000000366
  • Dergi Adı: MELANOMA RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.380-382
  • Anahtar Kelimeler: ipilimumab, liver, melanoma, toxicity
  • Erciyes Üniversitesi Adresli: Evet

Özet

Ipilimumab is a monoclonal antibody that exerts its effects by inhibiting the cytotoxic T-lymphocyte-associated protein 4 receptor on cytotoxic T lymphocytes. It is frequently used for the treatment of unresectable or metastatic melanoma. Ipilimumab may lead to several immune-related disease including colitis, thyroiditis, pneumonia, hepatitis, or pancreatitis as a side effect. Limited number of cases with hepatic damage as an ipilimumab-related adverse event has been reported in the literature. This agent has been implicated in causing acute hepatitis-like liver injury. Here, we presented a case in which cholestatic hepatitis developed during ipilimumab use for the treatment of metastatic melanoma.