Cytotoxic Activity Evaluation of Three New Metal Complexes
Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi, cilt.14, sa.1, ss.306-313, 2021 (TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14 Sayı: 1
- Basım Tarihi: 2021
- Doi Numarası: 10.18185/erzifbed.875774
- Dergi Adı: Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi
- Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.306-313
- Erciyes Üniversitesi Adresli: Evet
Özet
Abstract
Salicylaldehyde and 1-amino-5-(4-methylbenzoyl)-4-p-tolylpyrimidin-2(1H)-one were used for preparing a
Schiff base, which is 1-(2-hydroxybenzylideneamino)-5-(4-methylbenzoyl)-4-p-tolylpyrimidin-2(1H)-one
(S1). Three new complexes (Ag(I), Pd(II), and Pt(II)) were synthesized from this chelate ligand (S1). The
Ag(I) complex was screened against the human colon cancer cell line, and the silver complex was found to
have more cytotoxic activity than a standard drug used.