Reactivity of some pyrazole-3-carboxylic acid derivatives towards Grignard reagent


Korkusuz E. , YILDIRIM İ.

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol.56, no.2, pp.152-159, 2017 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 2
  • Publication Date: 2017
  • Title of Journal : INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
  • Page Numbers: pp.152-159

Abstract

Treatment of 1H-pyrazole-3-carboxylic acid derivatives with methylmagnesium chloride results in the formation of 1-aryl-5-phenyl-4-(1-phenyletheny1)-1H-pyrazoles 5,7, furo-pyrazolones 6, 4-substituted-3-(1-hyaroxy-l-methylethyl) -1,5-diaryl-1H-pyrazoles 8,9 and 3-acy1-4-(1-hydroxy-1-phenylethyl)-1-ary1-5-pheny1-1H-pyrazoles 11,13. The structures of all new synthesized compounds have been established by H-1, and C-13 NMR, as well as 2D COSY, FT-IR. spectroscopic data, and elemental analyses.