Reactivity of some pyrazole-3-carboxylic acid derivatives towards Grignard reagent


Korkusuz E. , YILDIRIM İ.

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, cilt.56, ss.152-159, 2017 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 56 Konu: 2
  • Basım Tarihi: 2017
  • Dergi Adı: INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
  • Sayfa Sayıları: ss.152-159

Özet

Treatment of 1H-pyrazole-3-carboxylic acid derivatives with methylmagnesium chloride results in the formation of 1-aryl-5-phenyl-4-(1-phenyletheny1)-1H-pyrazoles 5,7, furo-pyrazolones 6, 4-substituted-3-(1-hyaroxy-l-methylethyl) -1,5-diaryl-1H-pyrazoles 8,9 and 3-acy1-4-(1-hydroxy-1-phenylethyl)-1-ary1-5-pheny1-1H-pyrazoles 11,13. The structures of all new synthesized compounds have been established by H-1, and C-13 NMR, as well as 2D COSY, FT-IR. spectroscopic data, and elemental analyses.