FOXM1 transcriptionally regulates expression of integrin beta 1 in triple-negative breast cancer

Hamurcu Z., KAHRAMAN N., ASHOUR A., OZPOLAT B.

BREAST CANCER RESEARCH AND TREATMENT, cilt.163, sa.3, ss.485-493, 2017 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 163 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s10549-017-4207-7
  • Dergi Adı: BREAST CANCER RESEARCH AND TREATMENT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.485-493
  • Anahtar Kelimeler: Breast cancer, Triple-negative breast cancer, TNBC, FOXM1, siRNA, Invasion, Metastasis, Treatment, Transcription factor, Oncogene, FAK, Integrin beta 1, FOCAL ADHESION KINASE, CELL INVASION, BETA-1-INTEGRIN, MIGRATION, ACTIVATION, IDENTIFICATION, TUMORIGENESIS, SUPPRESSION, METASTASIS, PROGNOSIS
  • Erciyes Üniversitesi Adresli: Evet

Özet

Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer and associated with early metastasis, drug resistance, and poor patient survival. Fork head box M1 (FOXM1) is considered as an emerging molecular target due to its oncogenic role and high overexpression profile in 85% in TNBC. However, molecular mechanisms by which FOXM1 transcription factor mediate its oncogenic effects are not fully understood. Integrin beta 1 is often upregulated in invasive breast cancers and associated with poor clinical outcome and shorter overall patient survival in TNBC. However, the mechanisms regulating integrin beta 1 (ITGB1) gene expression have not been well elucidated.