FOXM1 transcriptionally regulates expression of integrin beta 1 in triple-negative breast cancer

Hamurcu Z., KAHRAMAN N., ASHOUR A., OZPOLAT B.

BREAST CANCER RESEARCH AND TREATMENT, vol.163, no.3, pp.485-493, 2017 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 163 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.1007/s10549-017-4207-7
  • Journal Name: BREAST CANCER RESEARCH AND TREATMENT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.485-493
  • Keywords: Breast cancer, Triple-negative breast cancer, TNBC, FOXM1, siRNA, Invasion, Metastasis, Treatment, Transcription factor, Oncogene, FAK, Integrin beta 1, FOCAL ADHESION KINASE, CELL INVASION, BETA-1-INTEGRIN, MIGRATION, ACTIVATION, IDENTIFICATION, TUMORIGENESIS, SUPPRESSION, METASTASIS, PROGNOSIS
  • Erciyes University Affiliated: Yes

Abstract

Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer and associated with early metastasis, drug resistance, and poor patient survival. Fork head box M1 (FOXM1) is considered as an emerging molecular target due to its oncogenic role and high overexpression profile in 85% in TNBC. However, molecular mechanisms by which FOXM1 transcription factor mediate its oncogenic effects are not fully understood. Integrin beta 1 is often upregulated in invasive breast cancers and associated with poor clinical outcome and shorter overall patient survival in TNBC. However, the mechanisms regulating integrin beta 1 (ITGB1) gene expression have not been well elucidated.