Reactions of aminopyrimidine derivatives with chloroacetyl and isophthaloyl chlorides
HETEROATOM CHEMISTRY, cilt.29, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29
- Basım Tarihi: 2018
- Doi Numarası: 10.1002/hc.21458
- Dergi Adı: HETEROATOM CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: aminopyrimidine, isophthalimide, Mizoroki-Heck coupling reaction, pyrimidin-[1(2H)-yl]acetamide, synthesis, MIZOROKI-HECK, PYRIMIDINE, ANALOGS
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Erciyes Üniversitesi Adresli: Evet
Özet
1-Aminopyrimidine-2-one derivatives (1a-c) were prepared in two steps from furan-2,3-diones and semicarbazones in toluene/benzene. Pyrimidin-[1(2H)-yl] acetamide derivatives and isophthalimide derivatives were synthesized from the nucleophilic acyl substitution reactions of compounds 1a-c with chloroacetyl chloride. The structures of compounds 2a-f were verified by IR, H-1 NMR, C-13 NMR and elemental analyses. The obtained final organic compounds were tested as catalysts in the Mizoroki-Heck coupling reaction. They mostly exhibited very high catalytic activity results for the coupling reaction of styrene with different aryl bromide derivatives.