Oral tadalafil reduces intra-abdominal adhesion reformation in rats

Kutuk, Mehmet; ÖZGÜN, MAHMUT; Batukan, Cem; ÖZÇELİK, BÜLENT; BAŞBUĞ, Mustafa; ÖZTÜRK, AHMET

doi:10.1093/humrep/der439

Oral tadalafil reduces intra-abdominal adhesion reformation in rats

Kutuk M. S., ÖZGÜN M. T., Batukan C., ÖZÇELİK B., BAŞBUĞ M., ÖZTÜRK A.

HUMAN REPRODUCTION, cilt.27, sa.3, ss.733-737, 2012 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 27 Sayı: 3
Basım Tarihi: 2012
Doi Numarası: 10.1093/humrep/der439
Dergi Adı: HUMAN REPRODUCTION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.733-737
Anahtar Kelimeler: adhesion reformation, tadalafil, rat, phosphodiesterase-5 inhibitor, post-operative adhesions
Erciyes Üniversitesi Adresli: Evet

Özet

Currently, there is no ideal agent to prevent adhesion formation. We have shown that sildenafil, a phosphodiesterase-5 (PDE-5) inhibitor, reduces post-operative adhesion formation by vasodilatation and increases fibrinolytic activity. Here, we evaluated whether tadalafil, a long-acting PDE-5 inhibitor, decreases post-operative adhesion reformation in rats.