Oral tadalafil reduces intra-abdominal adhesion reformation in rats

Kutuk, Mehmet; ÖZGÜN, MAHMUT; Batukan, Cem; ÖZÇELİK, BÜLENT; BAŞBUĞ, Mustafa; ÖZTÜRK, AHMET

doi:10.1093/humrep/der439

Oral tadalafil reduces intra-abdominal adhesion reformation in rats

Kutuk M. S., ÖZGÜN M. T., Batukan C., ÖZÇELİK B., BAŞBUĞ M., ÖZTÜRK A.

HUMAN REPRODUCTION, vol.27, no.3, pp.733-737, 2012 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 27 Issue: 3
Publication Date: 2012
Doi Number: 10.1093/humrep/der439
Journal Name: HUMAN REPRODUCTION
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.733-737
Keywords: adhesion reformation, tadalafil, rat, phosphodiesterase-5 inhibitor, post-operative adhesions
Erciyes University Affiliated: Yes

Abstract

Currently, there is no ideal agent to prevent adhesion formation. We have shown that sildenafil, a phosphodiesterase-5 (PDE-5) inhibitor, reduces post-operative adhesion formation by vasodilatation and increases fibrinolytic activity. Here, we evaluated whether tadalafil, a long-acting PDE-5 inhibitor, decreases post-operative adhesion reformation in rats.