Oral tadalafil reduces intra-abdominal adhesion reformation in rats

Kutuk M. S. , ÖZGÜN M. T. , Batukan C., ÖZÇELİK B. , BAŞBUĞ M. , ÖZTÜRK A.

HUMAN REPRODUCTION, vol.27, no.3, pp.733-737, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1093/humrep/der439
  • Title of Journal : HUMAN REPRODUCTION
  • Page Numbers: pp.733-737


Currently, there is no ideal agent to prevent adhesion formation. We have shown that sildenafil, a phosphodiesterase-5 (PDE-5) inhibitor, reduces post-operative adhesion formation by vasodilatation and increases fibrinolytic activity. Here, we evaluated whether tadalafil, a long-acting PDE-5 inhibitor, decreases post-operative adhesion reformation in rats.