Synthesis, Anticancer Activity on Prostate Cancer Cell Lines and Molecular Modeling Studies of Flurbiprofen-Thioether Derivatives as Potential Target of MetAP (Type II)

Yilmaz O., Bayer B., Bekci H., Uba A., CUMAOĞLU A., YELEKÇİ K., ...Daha Fazla

MEDICINAL CHEMISTRY, cilt.16, sa.6, ss.735-749, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1573406415666190613162322
  • Dergi Adı: MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.735-749
  • Erciyes Üniversitesi Adresli: Evet

Özet

Background: Prostate cancer is still one of the serious causes of mortality and morbidity in men. Despite recent advances in anticancer therapy, there is a still need of novel agents with more efficacy and specificity in the treatment of prostate cancer. Because of its function on angiogenesis and overexpression in the prostate cancer, methionine aminopeptidase-2 (MetAP-2) has been a potential target for novel drug design recently.