Vitamin D deficiency in patients with aggressive periodontitis

Anbarcioglu E., Kirtiloglu T., Ozturk A., Kolbakir F., Acikgoz G., Colak R.

ORAL DISEASES, cilt.25, sa.1, ss.242-249, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1111/odi.12968
  • Dergi Adı: ORAL DISEASES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.242-249
  • Anahtar Kelimeler: aggressive periodontitis, inflammatory diseases, risk factor, vitamin D deficiency, TANDEM MASS-SPECTROMETRY, CALCIUM SUPPLEMENTATION, SERUM CONCENTRATIONS, ASSOCIATION, DISEASE, TUBERCULOSIS, RECEPTORS, INDUCTION, LATITUDE, D-3
  • Erciyes Üniversitesi Adresli: Hayır

Özet

Objectives Vitamin D deficiency is a frequent health problem worldwide, especially as fewer people spend much time in the sun. Vitamin D deficiency is linked to several infectious and inflammatory conditions, including periodontal disease. However, its role in aggressive periodontitis (AgP) has not been well studied. We evaluated the association between vitamin D concentration and periodontal disease, both AgP and chronic (CP) periodontitis. Method and Materials Forty-seven AgP 55 CP and 27 control subjects participated. All patients were tested for serum vitamin D concentration (25(OH)D), parathyroid hormone, and serum bone-related biomarkers (alkaline phosphatases, calcium, and phosphorus) regulated by vitamin D. Results The patients with AgP had lower serum 25(OH)D concentration (11.22 +/- 4.8 ng/ml) than controls (16.9 +/- 6.4 ng/ml) and patients with CP (16.13 +/- 8.3 ng/ml; overall p value 0.0002). These associations remained significant after adjustment for age and gender (p = 0.002). No significant differences were observed in any bone-related biomarker among the three groups, and no association was observed with periodontal disease indices. Conclusions Our results suggest that vitamin D deficiency may be a potential risk factor for AgP. Given the high prevalence of vitamin D deficiency in AgP patients, routine screening for vitamin D status may be advisable in these subjects.