Red Blood Cell Distribution Width in 'Non-Dippers' versus 'Dippers'


Gunebakmaz O. , KAYA M., Duran M. , Akpek M. , ELÇİK D. , ERYOL N. K.

CARDIOLOGY, cilt.123, ss.154-159, 2012 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 123 Konu: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1159/000342667
  • Dergi Adı: CARDIOLOGY
  • Sayfa Sayısı: ss.154-159

Özet

Objectives: Because both high red cell distribution width (RDW) and non-dipping hypertension are closely related to adverse cardiovascular outcomes and higher inflammatory status, we aimed to investigate whether there is any relationship between RDW and dipping/non-dipping hypertension status. Methods: The present study involved 123 hypertensive patients and 65 age-and gender-matched healthy, normotensive subjects. Hypertensive patients were divided into two groups: 56 dipper patients (20 males, mean age 51.9 +/- 15.3 years) and 67 non-dipper patients (27 males, mean age 55.6 +/- 15.0 years). If the systolic daytime blood pressure (BP) of the patients decreased by at least 10% during the night-time, these subjects were 'dippers', and all other subjects were 'non-dippers'. Results : Both dipper patients and non-dipper patients had higher levels of RDW compared to normotensives (13.5 +/- 0.89 and 14.1 +/- 1.33 vs. 13.0 +/- 1.42%, p = 0.027 and p <0.001, respectively). Also RDW values in non-dippers were statistically higher compared to those in dippers (p = 0.008). Although there were negative correlations between RDW values and nocturnal systolic BP fall (p = 0.027, r = -0.199) and diastolic BP fall (p = 0.383, r = -0.079) in all hypertensive patients, these correlations did not reach a statistically significant level. Conclusion: Our study demonstrates that non-dippers have high RDW levels compared to both dippers and controls. Copyright (C) 2012 S. Karger AG, Basel