New NH-substituted 1,4-naphtho- and 1,4-benzo- quinones: Synthesis, characterization and potential antiproliferative effect against MDA-MB-231 cells

Kacmaz A., HAMURCU Z.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, cilt.193, sa.12, ss.831-839, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 193 Sayı: 12
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/10426507.2018.1514503
  • Dergi Adı: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.831-839
  • Anahtar Kelimeler: 1,4-Naphthoquinone, p-Benzoquinone, X-Ray structure determination, MDA-MB-231 cells, BIOLOGICAL EVALUATION, NAPHTHOQUINONES, DERIVATIVES, ANTIFUNGAL, SPECTRA, ANALOGS, REDOX, AMINO
  • Erciyes Üniversitesi Adresli: Evet

Özet

Eleven new alkyl and aryl amino quinones were synthesized from quinones (2,3-dibromo-1,4-naphthoquinone 1, 2-bromo-1,4-naphthoquinone 2, p-benzoquinone 3 or 2,6-dichloro-1,4-benzoquinone 8) with primary amines. The structures of all compounds were characterized by spectroscopic technics and elemental analysis. The structure of 2-((6,6-Dimethylbicyclo[3.1.1]heptan-2-yl)methylamino)-3-bromonaphthalene-1,4-dione (5a) was established by single crystal diffraction. 2-(2-(Ethylthio)ethylamino)naphthalene-1,4-dione (6b) was found to have noteworthy antiproliferative effect against MDA-MB-231 cells.