Effect of N-acetylcysteine on cisplatin induced apoptosis in rat kidney

Gunturk I., Seydel G. S., Dagli F., YAY A. H., YAZICI C., Kose K.

CUKUROVA MEDICAL JOURNAL, cilt.47, sa.2, ss.519-525, 2022 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.17826/cumj.783088
  • Dergi Adı: CUKUROVA MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.519-525
  • Anahtar Kelimeler: Cisplatin, apoptosis, N-acetylcysteine, Rat, TUNEL, INDUCED NEPHROTOXICITY, MECHANISMS, STRESS
  • Erciyes Üniversitesi Adresli: Evet

Özet

Purpose: Cisplatin is one of the most potent and widely used chemotherapeutic agents for the treatment of a wide variety of solid organ cancers. However, due to various side-effects such as nephrotoxicity, its therapeutic applications are limited. In the current study, it was aimed to investigate the effects of N-acetylcysteine (NAC), which is an effective antioxidant and anti-inflammatory agent, on cisplatin-induced apoptosis in rat kidneys.