Tuberculosis masked by immunodeficiency: a review of two cases diagnosed with chronic granulomatous disease


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NACAROĞLU H. T. , Bahceci Erdem S., Gulez N., Unsal Karkiner C. S. , Devrim I., GENEL F., ...Daha Fazla

TUBERKULOZ VE TORAK-TUBERCULOSIS AND THORAX, cilt.65, ss.56-59, 2017 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 65 Konu: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5578/tt.22093
  • Dergi Adı: TUBERKULOZ VE TORAK-TUBERCULOSIS AND THORAX
  • Sayfa Sayıları: ss.56-59

Özet

Chronic granulomatous disease (CGD) is a genetically heterogeneous primary immunodeficiency that is characterized by recurrent and life-threatening infections resulting from defects in phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system and granuloma formation due to increased inflammatory response. The most commonly involved organs are the lungs, skin, lymph nodes, and liver due to infection. It may present with recurrent pneumonia, hilar lymphadenopathy, empyema, abscess, reticulonodular patterns, and granulomas due to lung involvement. In recent years, mycobacterial disease susceptibility has been reported in CGD cases. This article presents two male cases, one of whom is aged 18 months and the other is aged 5 years, who were diagnosed with CGD and tuberculosis during examination due to extended pneumonia. This report is presented because CGD should be considered not only in the presence of skin abscesses and Aspergillus infections, but also in the differential diagnosis for cases with BCG-itis and/or tuberculosis. It should be kept in mind that mycobacterial infections can occur during the course of the disease.