An investigation of the association of GDF9-c.260G>A polymorphism with lamb live weight in the Akkaraman breed

Creative Commons License

Kökkaya Ş., DALDABAN F., BAYRAM D., ÇINAR M. U., ARSLAN K., AKYÜZ B.

Turkish Journal of Veterinary and Animal Sciences, cilt.49, sa.4, ss.144-150, 2025 (SCI-Expanded, Scopus, TRDizin) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 4
  • Basım Tarihi: 2025
  • Doi Numarası: 10.55730/1300-0128.4383
  • Dergi Adı: Turkish Journal of Veterinary and Animal Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.144-150
  • Anahtar Kelimeler: Akkaraman, growth differentiation factor-9 gene, Lamb, live weight
  • Erciyes Üniversitesi Adresli: Evet

Özet

In this study, the relationship between the Growth Differentiation Factor-9 (GDF9) gene polymorphism and birth weight, as well as weights on days 30, 60, 90, was investigated in Akkaraman lambs, one of the indigenous sheep breeds of Türkiye. For this purpose, a total of 314 lambs were genotyped by PCR-RFLP method for the single nucleotide polymorphism (SNP) c.260G>A in the GDF9 gene. While GG and GA genotypes were observed in the studied breed, the AA genotype was not observed. The results showed that Akkaraman lambs were in Hardy–Weinberg (H–W) equilibrium for the GDF9-c.260G>A polymorphism (p < 0.05). In this study, a significant association was observed between GDF9-HhaI polymorphism and 30th day weight and 60th day weight in Akkaraman lambs. When the animals were analyzed according to birth type, it was observed that this factor was associated with birth weight, as well as weights on days 30, 60, and 90. It is suggested that the c.260G>A coded SNP of the GDF9 gene has potential use in increasing lamb live weight from birth to weaning.