Akademik Veri Yönetim Sistemi
Diğer, ss.1006, 2017
Cancer is a very common disease between men and women in worldwide. Although many
studies have been conducted to find effective anticancer drugs by researchers, this disease is not
completely exterminated. 2-Nitrilebenzyl substituted benzimidazolium salt was obtained in
moderate yield (Scheme 1). The cytotoxic effect of the synthesized ligand were tested against two
human cancer cell lines and one non-cancerous cell line. According to obtained results; compound 2
have anticancer effect. Furthermore; we conducted a study on the formation; catalytic activity and
stability of hybrid nanoflowers (hNFs) containing benzimidazolium salt and copper ions. The
synthesis of hNFs was accomplished using a modified method. In all activity measurement
experiments; the hNFs and an identical concentration of free benzimidazolium salt was used. The
activities of hNFs were determined by colorimetric and spectroscopic methods using guaiacol as a
chromogenic substrate.The hNFs were characterized using SEM, EDX, FT-IR analysis, Bradford
assay, UV-Vis spectrometry and XRD. The effect of reaction temperatures on the morphology of the
hNFs is demonstrated with SEM images (Figure 1).