Effect of a Synthesized Compound against Cancerous Cell Line and Synthesis of Copper Ion Incorporated 1-(3,4-Diaminophenyl) Ethanone-Based Hybrid Nanoflowers


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Somtürk Yılmaz B. , Akkoç S., Özdemir N.

Diğer, ss.1006, 2017

  • Basım Tarihi: 2017
  • Sayfa Sayıları: ss.1006

Özet

Cancer is a very common disease between men and women in worldwide. Although many studies have been conducted to find effective anticancer drugs by researchers, this disease is not completely exterminated. 2-Nitrilebenzyl substituted benzimidazolium salt was obtained in moderate yield (Scheme 1). The cytotoxic effect of the synthesized ligand were tested against two human cancer cell lines and one non-cancerous cell line. According to obtained results; compound 2 have anticancer effect. Furthermore; we conducted a study on the formation; catalytic activity and stability of hybrid nanoflowers (hNFs) containing benzimidazolium salt and copper ions. The synthesis of hNFs was accomplished using a modified method. In all activity measurement experiments; the hNFs and an identical concentration of free benzimidazolium salt was used. The activities of hNFs were determined by colorimetric and spectroscopic methods using guaiacol as a chromogenic substrate.The hNFs were characterized using SEM, EDX, FT-IR analysis, Bradford assay, UV-Vis spectrometry and XRD. The effect of reaction temperatures on the morphology of the hNFs is demonstrated with SEM images (Figure 1).