pK(a) Determinations for Montelukast Sodium and Levodropropizine

NARİN I., Sarioglan S., Anilanmert B., Sari H.

JOURNAL OF SOLUTION CHEMISTRY, cilt.39, sa.10, ss.1582-1588, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 10
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s10953-010-9604-z
  • Dergi Adı: JOURNAL OF SOLUTION CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1582-1588
  • Anahtar Kelimeler: Potentiometric titration, Drug research, Acidity, Protonation, Dissociation constant, Ionization
  • Erciyes Üniversitesi Adresli: Evet

Özet

The pK (a) constants and relative abundances of unionized and ionized forms of Montelukast sodium {the sodium salt of 2-[1-[[(1R)-1-[3-[2-(7-chloroquinolin-2-yl)ethenyl] phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid} and Levodropropizine {(2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol} were determined potentiometrically from measurements at various pHs. These determinations were in order to relate their pK (a) values with their bioavailability and to provide chemical data to be used in their analysis.