The utility of serum neutrophil gelatinase-associated lipocalin level on predicting autosomal dominant polycystic kidney disease progression

UYSAL C., Koyuncu S., Ipekten F., KARAKÜKCÜ Ç., KOÇYİĞİT İ.

THERAPEUTIC APHERESIS AND DIALYSIS, vol.28, no.5, pp.760-768, 2024 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 5
  • Publication Date: 2024
  • Doi Number: 10.1111/1744-9987.14163
  • Journal Name: THERAPEUTIC APHERESIS AND DIALYSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, MEDLINE
  • Page Numbers: pp.760-768
  • Keywords: hypertension, neutrophil gelatinase-associated lipocalin, polycystic kidney disease, prognosis
  • Erciyes University Affiliated: Yes

Abstract

Introduction: We focused on neutrophil gelatinase-associated lipocalin (NGAL) and autosomal dominant polycystic kidney disease (ADPKD) progression. Methods: ADPKD patients with an estimated glomerular filtration rate (eGFR) >= 30 mL/min/1.73 m(2) were included. Serum NGAL level and NGAL to eGFR ratio (NGR), height-adjusted total kidney volume (hTKV) were assessed initially. Patients were followed-up for 5 years. Results: Sixty one patients were enrolled and initial eGFR was 73.6 (48.9-101.5) ml/min/1.73m(2). EGFR declined by 3.7 mL/min/1.73m(2) per year. Thirty four patients (55.7%) exhibited rapid progression. Rapid progression group had lower serum NGAL levels (p < 0.001) and higher hTKV (p < 0.001). Lower serum NGAL level was a risk factor for rapid progression (p < 0.001). NGR was not associated with rapid progression. Serum NGAL level was predictive in for rapid progression ROC analysis (cut-off <10.62 ng/mL). Conclusion: Relatively lower serum NGAL levels can predict worse outcomes in ADPKD and can provide risk stratification in patients with ADPKD.