The effect of diabetes mellitus and end-stage renal disease on the number of CD34+ cells in the blood

Pala C., ALTUN I., Koker Y., Kurnaz F., Sivgin S., KOÇYİĞİT I., ...More

ANNALS OF HEMATOLOGY, vol.92, no.9, pp.1189-1194, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 92 Issue: 9
  • Publication Date: 2013
  • Doi Number: 10.1007/s00277-013-1760-y
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1189-1194
  • Keywords: Diabetic nephropathy, End-stage renal disease, Hematopoietic stem cell, ENDOTHELIAL PROGENITOR CELLS, VASCULAR COMPLICATIONS, REPAIR
  • Erciyes University Affiliated: Yes


The aim of this study was to investigate the effect of end-stage renal disease (ESRD) and diabetes mellitus (DM) on the number of stem cells in the peripheral blood. Sixty-two patients diagnosed with ESRD who had not received dialysis previously, 25 patients with a diagnosis of DM without nephropathy, and 21 healthy volunteers were included in the study. The group diagnosed with ESRD was divided into two groups. The first group (DM-CRD) consisted of 28 patients with DM who had developed chronic renal disease (CRD). The second group (NON-DM-CRD) consisted of 34 patients without DM who had CRD by etiology. The routine complete blood count, renal function, and number of CD34+ cells were determined for all of those involved in the study. The microalbumin/creatinine levels were measured, and glomerular filtration rates were calculated in all patients. The number of CD34+ cells was found to be significantly lower in the DM control group and DM-CRD group compared with the healthy group. No statistically significant difference was found between the NON-DM-CRD and the healthy control group. There was a moderate negative correlation between the ratio of microalbumin/creatinine and the number of CD34+ cells. A significant reduction in the number of CD34+ cells was shown in subjects with DM and ESRD caused by diabetic nephropathy.