Akademik Veri Yönetim Sistemi
Journal of Vascular and Interventional Radiology, cilt.37, sa.8, 2026 (SCI-Expanded, Scopus)
Purpose: To evaluate the safety and diagnostic performance of ultrasound (US)-guided omental core needle biopsy (CNB) using a composite reference standard, compare conventional and coaxial techniques, and assess the complementary role of ascitic fluid cytology. Materials and Methods: In this single-center retrospective cohort study, 463 patients (354 female and 109 male; median age, 64 years) with suspected omental disease who underwent US-guided omental CNB between January 2010 and December 2025 were included. Standard contraindications (eg, uncorrected coagulopathy) were respected. No additional exclusion criteria were applied. Biopsy results were correlated with surgical pathology or clinical-radiologic follow-up. Primary endpoints were diagnostic performance metrics and procedure-related adverse events. Subgroup comparisons were performed using Fisher exact test, with P < .05 considered statistically significant. Results: Technical success was achieved in 98.7% (457/463) of procedures, with no procedure-related adverse events. Overall, CNB demonstrated a sensitivity of 90.3%, specificity of 100%, and diagnostic accuracy of 93.3%. After repeat CNB in discordant cases, sensitivity increased to 95.0%, and diagnostic accuracy increased to 96.5%. Coaxial CNB demonstrated higher sensitivity (92.7% vs 85.3%, P = .043) and diagnostic accuracy (95.0% vs 89.4%, P = .041) than conventional CNB. Ascitic fluid cytology showed sensitivity ranging from 65.1% to 76.7% depending on the interpretative threshold. Conclusions: US-guided omental CNB is a safe, minimally invasive approach, achieving high diagnostic accuracy with an excellent safety profile in an outpatient setting. The coaxial technique demonstrated higher diagnostic accuracy and sensitivity. Ascitic fluid cytology provided complementary diagnostic information, particularly in cases with false-negative biopsy results.