Akademik Veri Yönetim Sistemi
Journal of Inonu University Vocational School of Health Services, cilt.14, sa.1, ss.127-137, 2026 (Scopus, TRDizin)
The increase in antimicrobial resistance necessitates the development of new therapeutics. In this context, silver nanoparticles (AgNPs) show considerable promise due to their multiple anti-microbial mechanisms, including cell wall disruption, oxidative stress, and DNA damage, as well as their relatively low toxicity. The effectiveness of AgNPs depends on their size, shape, and surface modifications; their combination with ligands can also produce synergistic effects. In this study, cloxacillin sodium (a β-lactam antibiotic) was employed as a ligand to synthesize Clox@ AgNPs via photoreduction under UV irradiation (311 nm). The characteristic absorbance peak, morphology, surface charge, and diameter of the Clox@AgNPs were analyzed using UV–visible spectroscopy, scanning transmission electron microscopy, Fourier-transform infrared spectros-copy, dynamic light scattering, and zeta potential analysis. The antibacterial activity of Clox@ AgNPs against methicillin-resistant Staphylococcus aureus (MRSA) was then evaluated for its potential to enhance the efficacy of existing antibiotics. This approach may provide a valuable contribution to future antimicrobial strategies.