Progression of aortic stenosis and associated heavy metal in blood

Elçik D., Altunel E., Cesur B., Çetinkaya Z., Topsakal R., Kalay N.


  • Publication Type: Conference Paper / Full Text
  • City: Antalya
  • Country: Turkey
  • Erciyes University Affiliated: Yes


Aortic stenosis (AD) is the most common cardiopulmonary disease, and with the increase in elderly population, the frequency is increasing in developed countries. Degenerative / calcific aortic stenosis is a very common disease in developed societies, 21-26% in people over 65 years old and 48% in people over 85 years old. The rate of progression of aortic stenosis and the factors affecting it are known; it is important that the rate of progress can be slowed down by treatment approaches for these factors, if there are controllable risk factors that affect the rate of progression, and which patients should be assessed on a frequent basis. We considered the effects of heavy metals on the aortic valve progression, taking into consideration the increasing environmental pollution conditions.
METHODS:A total of 55 patients (33 patients with mild AD and 22 patients with moderate AD) were included in the study, who had mild to moderate AD with a calcified aortic valve over 50 years of age who were diagnosed with aortic stenosis between 2011 and 2014. Patients' blood heavy metal levels and progression status (mean 3-year follow-up) were studied.
RESULTS:There were two groups of patients showing progressive and non-progressive follow-up. Twenty-six patients in the progressive group and 29 in the non-progressive group were identified. Baseline characteristics were similar between the two groups. A significant difference was found between zinc, chromium, magnesium and selenium in blood heavy metal levels (p <0.001), there was no correlation with copper (p = 0,1) (figure 1). Progression in the group with mild aortic stenosis was seen more (19 vs 7).
CONCLUSIONS:Some findings have been obtained in our study that may help to understand the relationship between serum trace element levels and calcific AD severity and progression. Changes in the levels of tracer elements may cause oxidative stress and endothelial dysfunction leading to the development of calcific AD. Trace element levels may be indicative of rapid progression in patients with calcific AD.