34.ULUSLARARASI KATILIMLI TÜRK KARDİYOLOJİ KONGRESİ, Antalya, Türkiye, 20 - 23 Ekim 2018
stenosis (AD) is the most common cardiopulmonary disease, and with the increase
in elderly population, the frequency is increasing in developed countries.
Degenerative / calcific aortic stenosis is a very common disease in developed
societies, 21-26% in people over 65 years old and 48% in people over 85 years
old. The rate of progression of aortic stenosis and the factors affecting it
are known; it is important that the rate of progress can be slowed down by
treatment approaches for these factors, if there are controllable risk factors
that affect the rate of progression, and which patients should be assessed on a
frequent basis. We considered the effects of heavy metals on the aortic valve
progression, taking into consideration the increasing environmental pollution
METHODS:A total of 55 patients (33 patients with mild AD and 22 patients with
moderate AD) were included in the study, who had mild to moderate AD with a
calcified aortic valve over 50 years of age who were diagnosed with aortic
stenosis between 2011 and 2014. Patients' blood heavy metal levels and
progression status (mean 3-year follow-up) were studied.
RESULTS:There were two groups of patients showing progressive and
non-progressive follow-up. Twenty-six patients in the progressive group and 29
in the non-progressive group were identified. Baseline characteristics were
similar between the two groups. A significant difference was found between
zinc, chromium, magnesium and selenium in blood heavy metal levels (p
<0.001), there was no correlation with copper (p = 0,1) (figure 1).
Progression in the group with mild aortic stenosis was seen more (19 vs 7).
CONCLUSIONS:Some findings have been obtained in our study that may help to
understand the relationship between serum trace element levels and calcific AD
severity and progression. Changes in the levels of tracer elements may cause
oxidative stress and endothelial dysfunction leading to the development of
calcific AD. Trace element levels may be indicative of rapid progression in
patients with calcific AD.