Long-term clinical outcomes in living kidney donors: a comparative study with matched controls

KONTAŞ M. E., KOÇYİĞİT İ., SİPAHİOĞLU M. H., TOKGÖZ B.

International Urology and Nephrology, 2025 (SCI-Expanded, Scopus) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1007/s11255-025-04880-w
  • Dergi Adı: International Urology and Nephrology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Gender Studies Database
  • Anahtar Kelimeler: Living kidney donation, Kidney transplantation, Chronic kidney disease, Unilateral nephrectomy, Hypertension, Diabetes mellitus
  • Erciyes Üniversitesi Adresli: Evet

Özet

Purpose: This study aimed to assess the impact of kidney donation and pre-donation factors such as age and BMI, are associated with long-term outcomes like hypertension, diabetes and GFR decline. highlighting the importance of proper donor selection and long-term follow up. Methods: This study aims to assess long-term clinical outcomes, such as the development of hypertension, diabetes, proteinuria, and changes in kidney function, in living kidney donors following nephrectomy. Results: A cohort of 87 kidney donors from Erciyes University and a control group of 100 individuals with comparable demographics were monitored. Parameters such as blood pressure, BMI, GFR, and proteinuria levels were documented pre- and post-donation, and outcomes were compared within and between groups. Conclusion: Multiple regression analysis revealed nephrectomy as an independent risk factor for increased hypertension incidence (p = 0.002) and a persistent reduction in GFR exceeding 20% (p < 0.001). Advanced age at donation and post-donation BMI were associated with elevated risks of hypertension and diabetes.