One-Step Facile Surface Engineering of Hydrophobic Nanocrystals with Designer Molecular Recognition


Chen T., Oecsoy I. , YUAN Q., WANG R., YOU M., ZHAO Z., ...Daha Fazla

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, cilt.134, sa.32, ss.13164-13167, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 134 Konu: 32
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1021/ja304115q
  • Dergi Adı: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
  • Sayfa Sayıları: ss.13164-13167

Özet

High quality nanocrystals have demonstrated substantial potential for biomedical applications. However, being generally hydrophobic, their use has been greatly limited by complicated and inefficient surface engineering that often fails to yield biocompatible nanocrystals with minimal aggregation in biological fluids and active targeting toward specific biomolecules. Using chimeric DNA molecules, we developed a one-step facile surface engineering method for hydrophobic nanocrystals. The procedure is simple and versatile, generating individual nanocrystals with multiple ligands. In addition, the resulting nanocrystals can actively and specifically target various molecular addresses, varying from nucleic acids to cancer cells. Together, the strategy developed here holds great promise in generating critical technologies needed for biomedical applications of nanocrystals.