Adenosine deaminase enzyme activity is increased and negatively correlates with catalase, superoxide dismutase and glutathione peroxidase in patients with Behcet's disease: original contributions/clinical and laboratory investigations

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Erkilic K. , Evereklioglu C. , Cekmen M., Ozkiris A., Duygulu F. , Dogan H.

MEDIATORS OF INFLAMMATION, cilt.12, sa.2, ss.107-116, 2003 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 12 Konu: 2
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1080/0962935031000097754
  • Sayfa Sayıları: ss.107-116


Aim: Behcet's disease (BD) is an inflammatory vasculitis with immunologic, endothelial and neutrophil alterations. Adenosine deaminase (AD) is a marker of T-cell activation and is related to the production of reactive oxygen species by neutrophils with the production of NO., O-2(.-), H2O2 and OH.. We reported increased tumour necrosis factor-alpha, soluble interleukin-2 receptor, interleukin-6, interleukin-8 and NO. in active BD. As there is a relation between cytokines, T cells and oxidative stress in inflammatory diseases, this study further evaluated: (1) plasma AD activity and its correlation with acute phase reactants; (2) thiobarbituric acid-reactive substances (TBARS) as an indicator for lipid peroxidation; and (3) antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GSH Px ) and catalase in patients with BD. The effect of disease activity and correlations between the measured parameters were explored.