Investigation of ischemia-modified albumin levels and some atherosclerosis-related serum parameters in patients with diabetic foot

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Muhtaroğlu S., Keti D., Ünlühizarcı K.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.46, sa.1, ss.126-132, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3906/sag-1406-38
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.126-132
  • Anahtar Kelimeler: Diabetic foot, ischemia-modified albumin, oxidized low-density lipoprotein, paraoxonase 1, peripheral arterial disease, PARAOXONASE, LIPOPROTEIN, PLASMA, ARYLESTERASE, NEUROPATHY, OXIDATION, BINDING
  • Erciyes Üniversitesi Adresli: Evet

Özet

Background/aim: To investigate serum ischemia-modified albumin (IMA), oxidized low-density lipoprotein (ox-LDL) levels, and paraoxonase 1 (PON1) activity in patients with diabetic foot. Materials and methods: Thirty patients with diabetes mellitus (DM), 30 patients with diabetic foot (29 and 27 of these patients had type 2 DM, respectively), and 30 healthy volunteers as the control group were included in the study. The patients with diabetic foot were divided into 2 groups, as those who had or had not undergone lower extremity amputation. Serum PON1 activity, ox-LDL, and IMA levels were measured. Results: Serum PON1 activity was lower (P < 0.05) and ox-LDL levels were higher (P < 0.05) in the diabetic foot group than in the control and diabetes groups. Albumin-adjusted IMA values were higher (P < 0.001) in the diabetic foot group compared to the diabetes group. The postamputation levels of IMA were decreased compared to the preamputation condition (P < 0.05). Conclusion: The low activity of PON1 and the high levels of ox-LDL and IMA may play an important role in the pathogenesis of diabetic foot. The use of these parameters in the follow-up of patients with DM may prevent the development of diabetic foot. In order to reach a definitive judgment, further studies with a larger number of subjects are necessary.

Keywords

Diabetic foot, ischemia-modified albumin, oxidized low-density lipoprotein, paraoxonase 1, peripheral arterial disease