In-vitro studies on mechanisms of immunosuppression associated with bovine respiratory syncytial virus

Keles I., WOLDEHIWET Z., MURRAY R.

JOURNAL OF COMPARATIVE PATHOLOGY, cilt.118, sa.4, ss.337-345, 1998 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 118 Sayı: 4
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1016/s0021-9975(07)80009-0
  • Dergi Adı: JOURNAL OF COMPARATIVE PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.337-345
  • Erciyes Üniversitesi Adresli: Hayır

Özet

Bovine respiratory syncytial virus (BRSV) depressed the proliferative reactivity of normal ovine peripheral blood lymphocytes to phytohaemagglutinin (PHA). This BRSV-induced reduction in proliferative reactivity was not reversed or ameliorated by the addition of (1) indomethacin or flunixin meglumine, substances known to inhibit the production of prostaglandins, or (2) the cytokines, interleukin-1 (IL-1) and interleukin-2 (IL-2), or (3) rat growth factor. The results suggest that the suppression of ovine lymphocyte reactivity to PHA associated with BRSV was not caused by the release of cyclooxygenase products such as prostaglandins, or the production of inhibitors of IL-1 or IL-2. (C) 1998 W.B. Saunders Company Limited.