In-vitro studies on mechanisms of immunosuppression associated with bovine respiratory syncytial virus


Keles I. , WOLDEHIWET Z., MURRAY R.

JOURNAL OF COMPARATIVE PATHOLOGY, cilt.118, ss.337-345, 1998 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 118 Konu: 4
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1016/s0021-9975(07)80009-0
  • Dergi Adı: JOURNAL OF COMPARATIVE PATHOLOGY
  • Sayfa Sayıları: ss.337-345

Özet

Bovine respiratory syncytial virus (BRSV) depressed the proliferative reactivity of normal ovine peripheral blood lymphocytes to phytohaemagglutinin (PHA). This BRSV-induced reduction in proliferative reactivity was not reversed or ameliorated by the addition of (1) indomethacin or flunixin meglumine, substances known to inhibit the production of prostaglandins, or (2) the cytokines, interleukin-1 (IL-1) and interleukin-2 (IL-2), or (3) rat growth factor. The results suggest that the suppression of ovine lymphocyte reactivity to PHA associated with BRSV was not caused by the release of cyclooxygenase products such as prostaglandins, or the production of inhibitors of IL-1 or IL-2. (C) 1998 W.B. Saunders Company Limited.