Anticancer Role of Natural Phenolic Acids by Targeting Angiotensin-Converting Enzyme (ACE)
Advances in Biochemistry in Health and Disease, Springer Nature, ss.465-481, 2023
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2023
- Doi Numarası: 10.1007/978-3-031-23621-1_23
- Yayınevi: Springer Nature
- Sayfa Sayıları: ss.465-481
- Anahtar Kelimeler: Angiotensin-converting enzyme, Caffeic acid, Cancer prevention, Ellagic acid, Gallic acid, Phenolic acids
- Erciyes Üniversitesi Adresli: Evet
Özet
Recently, it has become obvious that renin-angiotensin system (RAS) plays an important role in cancer progression through angiotensin converting enzyme (ACE), involving activation and upregulation of multiple oncogenic molecules. Accordingly, suppression of ACE and its subsequent downstream cascades has received considerable attention as a possible way to combat oncological diseases. In this book chapter, the role of a several plant-derived phenolic acids (Ellagic acid, Gallic acid, Caffeic acid) on inhibition of ACE is demonstrated, and involvement of this action in chemopreventive and chemotherapeutic properties of these natural compounds is discussed, with a special focus on antiangiogenic and antiinflammatory activities.