Microchemical Journal, vol.207, 2024 (SCI-Expanded)
The development of efficient and eco-friendly sensing platforms for the sensitive detection of anticancer drugs like Ribociclib (RIB) is essential for advancing therapeutic monitoring and ensuring patient safety. In this study, we introduce a novel electrochemical sensor that utilizes a unique CuCoFe-MOF/CoFe2O4/banana peel activated carbon (BPAC) composite-modified carbon paste electrode (CPE) for the sensitive quantification of RIB. This composite material, which has not been previously reported in the literature, offers enhanced electrocatalytic activity, attributed to its increased surface area and superior conductivity. Various techniques, including FT-IR, XRD, SEM-EDX, and BET analysis, were used to confirm the structural and morphological properties of the synthesized composite. Differential pulse voltammetry (DPV) results showed a broad linear range of 0.2–9.7 μM and a remarkably low limit of detection (LOD) of 0.025 μM, demonstrating its high sensitivity. The sensor's performance was further validated in pharmaceutical formulations and biological samples, achieving recoveries between 98.6 % and 101.8 % with an RSD below 2.0 %. Additionally, the method was evaluated using the Green Analytical Procedure Index (GAPI), Analytical Greenness (AGREE), and Blue Applicability Grade Index (BAGI) tools, confirming that it is both green and highly applicable. This work presents a significant advancement in the field of electrochemical sensing for RIB detection, offering a novel, sustainable, and practical solution for real-world applications.