Prognostic importance of proliferating cell nuclear antigen immunoreactivity and mitotic index in malignant mesothelioma Mali̇gn mezotelyomada proli̇ferati̇ng nuclear cell anti̇jen i̇mmünreakti̇vi̇tesi̇ni̇n ve mi̇toti̇k i̇ndeksi̇n prognoza etki̇si̇

Soyuer I., CANÖZ Ö., Er Ö., DENİZ K., Soyuer S., Bilgin M., ...Daha Fazla

Erciyes Tip Dergisi, cilt.24, sa.3, ss.115-119, 2002 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 3
  • Basım Tarihi: 2002
  • Dergi Adı: Erciyes Tip Dergisi
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.115-119
  • Erciyes Üniversitesi Adresli: Evet

Özet

Aim: In this study, proliferating nuclear cell antigen (PCNA) immunoreactivity and the mitotix index were searched in human malignant mesothelioma to assess their prognostic value. Material and Methods: PCNA immunoreactivity was investigated in 19 cases. The authors also compared this with mitosis counts. Results: There was no correlation between the percentage of PCNA immunoreactive cells and their mitotic counts. However, the median survival was 16.4 months for patients with less than 25% PCNA immunoreactive cells, 17.8 months for patients with less than 4 mitotic figures 10 high power fields of tumoral tissue, 10.8 months for patients with more than 25 per cent PCNA immunoreactive cells, and 14.2 months for patients with more than 4 mitotic figures in 10 high power fields of tumoral tissue. Conclusion: Our results suggest that PCNA immunoreactivity and mitotic count may have prognostic values in malignant mesothelioma.