The effect of volume replacement during therapeutic leukapheresis on white blood cell reduction in patients with extreme leukocytosis


Kurnaz F., Sivgin S., Pala C. , yildirim R., Baldane S. , Kaynar L. , ...More

TRANSFUSION, vol.53, no.11, pp.2629-2634, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 11
  • Publication Date: 2013
  • Doi Number: 10.1111/trf.12141
  • Title of Journal : TRANSFUSION
  • Page Numbers: pp.2629-2634

Abstract

BackgroundExtreme leukocytosis, generally defined as a white blood cell (WBC) count of more than 100x10(9)/L consisting largely of blast cells, especially when accompanied by clinical signs and symptoms of leukostasis or hyperviscosity, often predicts a poor clinical outcome in patients with acute leukemia. In this study, we aimed to investigate the effect of volume replacement (VR) during therapeutic leukapheresis (TA) procedure on early mortality rate and WBC reduction.